Cisplatin kidney function

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August undefined, 2024

WebFeb 16, 2024 · Common side effects of cisplatin may include: hearing problems; kidney problems; numbness or tingling; nausea, vomiting; or. bone marrow suppression. This is … WebJan 3, 2024 · Assessment of kidney function; Bleomycin-induced lung injury; Chemotherapy and radiation-related hemorrhagic cystitis in cancer patients; …

Renal function of cancer patients "fit" for Cisplatin ... - PubMed

WebAug 22, 2015 · Cisplatin has a well-established role in the treatment of broad spectrum of malignancies; however its use is limited because of cisplatin-induced nephrotoxicity (CIN) which can be progressive in more than 50% of cases. WebDec 21, 2024 · Myo-inositol, a carbocyclic sugar, is believed to be relevant to renal pathobiology since the kidney is the major site for its catabolism. Its role in acute kidney injury (AKI) has not been fully investigated. Ferroptosis, a unique form of regulated cell death, is involved in various types of renal injuries. The relevance of myo-inositol with … darn tough boots

Cisplatin chemotherapy and renal function - PubMed

WebApr 14, 2024 · Since HK-2-cells-generated-Abs, both by cisplatin or upon UV light exposure, can induce apoptosis in HK-2 cells, the purpose of this work was to study their metabolome and therein find the molecular features which help us to unravel the mechanisms of that phenomenon. WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … WebFindings: In vivo, after celastrol treatment, cisplatin-induced kidney injury was significantly ameliorated as shown by the improvement of renal function (BUN, serum creatinine, … bisnow summit

Exploring the Metabolic Differences between Cisplatin

Cisplatin nephrotoxicity - UpToDate

WebAbstract Cisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad anticancer potential, its clinical use has regularly been constrained by kidney … WebAcute kidney injury is a known side effect of cisplatin treatment, and kidney dysfunction results in the accumulation of uremic toxins in the serum. The present study aimed to investigate whether indoxyl sulfate (IS), a representative uremic toxin, affects the pathophysiology of EOC. bisnow tysonsWebRenal function of cancer patients "fit" for Cisplatin chemotherapy: physician perspective Authors J Montoya 1 , H G Luna 2 , J R Amparo 2 , C Casasola 3 , G Cristal-Luna 2 Affiliations 1 Joey Montoya, MD, National … darn tough crew wool socks

"WebMar 1, 2024 · Acute kidney injury (AKI) is the main obstacle that limits the use of cisplatin in cancer treatment. Proton pump inhibitors (PPIs), the most commonly used class of medications for gastrointestinal complications in cancer patients, have been reported to cause adverse renal events. However, the effect … " - Cisplatin kidney function

Cisplatin kidney function

Cisplatin: uses, treatment and side effects - Netdoctor

WebApr 12, 2024 · GFR allows a correct assessment of kidney function in patients with cancer undergoing cisplatin therapy. Abbreviations: BSA, body surface area; CKD-EPI, chronic kidney disease epidemiology collaboration; CRF, chronic renal failure; GFR, estimated-glomerular filtration rate; FPA, furanpropanoic acid; PAH, P-Amminoippurate; uCrCl, … WebCisplatin(cis-dichlorodiammineplatinum)–platinum coordination complex is an effective chemotherapy against a wide spectrum of tumors such as testicular, head and neck, …

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WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. … WebFindings: In vivo, after celastrol treatment, cisplatin-induced kidney injury was significantly ameliorated as shown by the improvement of renal function (BUN, serum creatinine, and cystatin C), kidney morphology (PAS staining) and oxidative stress (MDA) and the suppression of renal tubular injury markers of KIM-1 and NGAL.

WebRenal toxicity is a prominent component of the toxicity profile of platinum-based chemotherapy. Kidney damage, once dose limiting for cisplatin, occurs in some patients who receive carboplatin and may occur with the third-generation platinum analog ormaplatin. WebKidney toxicity. Effects on kidney function are dose related, observed 10-20 days after therapy, and are generally reversible. Ototoxicity hearing loss, ringing in the ears. …

WebFeb 14, 2024 · Nevertheless, 40–50% of patients have impaired renal function that precludes the use of cisplatin. The non-nephrotoxic platinum analogue, carboplatin, has … WebMar 23, 2024 · Here, we postulated that systemically delivered rapamycin perfluorocarbon nanoparticles (PFC NP) could reach the injured kidneys at sufficient and sustained concentrations to mitigate cisplatin-induced acute kidney injury …

WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe …

WebJan 11, 2024 · Trials evaluating cisplatin-eligible patients use renal function thresholds ranging from 40 ml/min to 60 ml/min, whereas trials evaluating cisplatin-ineligible patients employ overlapping... bisnow tacoma bisnow wynwood conferenceWebAug 15, 2024 · Among nephrotoxic agents that cause AKI, cisplatin is a chemotherapeutic drug that has been extensively used for treating solid cancers including breast, pancreatic, colorectal, esophageal, blood, lung, bladder, and hepatocellular cancers (Holditch et al., 2024; Rottenberg et al., 2024). bisnow uk life sciencesWebJul 5, 2024 · Cisplatin may reduce the ability of the kidneys to excrete the medicines bleomycin and methotrexate and so may increase the risk of side effects from these medicines. Cisplatin may lower the... darn tough crew socksWebSep 1, 2014 · Acute kidney injury (AKI), previously called acute renal failure (ARF) , is defined as an abrupt onset of renal dysfunction ranging from minor loss of function to failure [7,8,9]. AKI is a common clinical complication that develops in approximately 4%–7% of hospitalized patients each year and the prognosis can be poor [ 10 , 11 ]. darn tough cushion levelsWebApr 25, 2014 · Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and … bisnow student housingWebJun 11, 2024 · Vagus nerve stimulation even after injury ameliorates cisplatin-induced nephropathy via reducing macrophage infiltration Scientific Reports Article Open Access Published: 11 June 2024 Vagus... darn tough customer service