Dysbindin function
WebApr 19, 2011 · Interactions between dysbindin-1 and necdin. To investigate dysbindin-1 function, a yeast two-hybrid screen was performed to identify novel partners of dysbindin-1. WebPrevious studies have indicated that dysbindin-1 functions in the regulation of synaptic activity. Recently, dysbindin-1 has also been documented to be involved in neuronal development. In this study, we identified necdin as a binding partner of dysbindin-1 using a yeast two-hybrid screen. Dysbindin-1 recruits necdin to the cytoplasm, thereby ...
Dysbindin function
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WebShao et al. (2011) reported that neuronal disruption of dysbindin function in drosophila was associated with hypoglutamatergic transmission and deficits in working memory, while disruption of dysbindin function in glial cells was associated with hyperdopaminergia and locomotor hyperactivity; this latter effects was mediated via a reduction in ... WebDysbindin definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
WebJan 18, 2024 · Genetic data suggest that dysbindin functions independently of presynaptic Ca 2+ influx 11. Interestingly, rim mutants … Webnormalities in synaptic morphology and function,22 were also documented. These important findings notwithstanding, the function of dysbindin in the brain remains unclear. Although its initial descrip-
WebMay 27, 2011 · Dysbindin (also known as dysbindin–1 or dystrobrevin-binding protein 1) was identified 10 years ago as a ubiquitously expressed protein of unknown function. In the following years, the protein and its encoding gene, DTNBP1 , have become the focus of intensive research owing to genetic and histopathological evidence suggesting a … WebAt the functional level, dysbindin plays a role in NMDAR function because sdy hippocampal neurons exhibit an upregulation of NR2A subunits and enhanced long-term potentiation (Tang et al., 2009). Dysbindin is a component of the multisubunit BLOC-1 ...
Dysbindin, short for dystrobrevin-binding protein 1, is a protein constituent of the dystrophin-associated protein complex (DPC) of skeletal muscle cells. It is also a part of BLOC-1, or biogenesis of lysosome-related organelles complex 1. Dysbindin was discovered by the research group of Derek Blake via yeast … See more Much interest in dysbindin has arisen through pedigree-based family-association studies of families with a history of schizophrenia, where a strong association was found between expression of a particular dysbindin … See more Dysbindin has been shown to interact with SNAPAP, MUTED and PLDN. See more • GeneReviews/NCBI/NIH/UW entry on Hermansky–Pudlak syndrome • Dysbindin at the U.S. National Library of Medicine Medical Subject Headings See more
WebNov 20, 2009 · The Drosophila homolog of DTNBP1 (dysbindin) was identified in the screen and was found to function during synapse development, baseline neurotransmission, and synaptic homeostasis. Dysbindin altered the calcium-dependence of vesicle release and was essential in the presynaptic neuron for both the induction and … curfew for adult child living at homeWebMay 27, 2011 · Dysbindin (also known as dysbindin-1 or dystrobrevin-binding protein 1) was identified 10 years ago as a ubiquitously expressed protein of unknown function. In the following years, the protein and its encoding gene, DTNBP1, have become the focus of intensive research owing to genetic and histopathol … easy frittataWebExpression of Dysbindin-1 in the Brain and Its Biological Functions Dysbindin-1 is a protein encoded by dystrobrevin-binding protein 1 gene ( DTNBP1 ), which is located on the short (p) arm of ... curfew essayWebDescribed as a 'hub', dysbindin is an important regulatory protein that is linked with multiple complexes in the brain and is involved in a wide variety of functions implicated in neurodevelopment and neuroplasticity. easy friendship casseroleWebFeb 19, 2010 · Background Dysbindin, a cytoplasmic protein long known to function in the biogenesis of specialized lysosome-related organelles (LROs), has been reported to reduce surface expression of D2 … curfew for 17 year olds in californiaWebFeb 15, 2024 · Dysbindin-1 restricts mitochondrial length. To test whether dysbindin-1 regulates organelles, we examined mitochondria in sdy mice, which carry a deletion mutation in the dysbindin-1 gene. easy frittata bakeWeb1 day ago · The GO enrichment analysis for cellular compartments and biological function was performed using PANTHER overrepresentation test (GO database released 1 January 2024) with FDR < 0.05 and with all ... curfew for bars in ny