Lck-cre mouse

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August undefined, 2024

WebThe Lck-Cre transgenic mouse uses the proximal promoter of the Lck (lymphocyte protein tyrosine kinase) gene, which is first expressed early in thymocyte development at the … Web2 aug. 2024 · Mice with conditional mutagenesis of Pten gene were first generated in 2001 by two groups. Suzuki et al. used the Cre-loxP system (expressing Cre recombinase under control of the Lck promoter) to generate a T cell-specific deletion of the Pten gene by targeting exons 4 and 5.

Lck-cre Transgenic Taconic Biosciences

WebDescription. The ATP competitive CDK inhibitors (CDK1/cyclinB, CDK2/cyclinA, CDK2/cyclinE and CDK5/p25 have IC50 values of 0.4, 0.68, 7.5, and 0.85 µM, respectively). It also inhibits GSK-3β and LCK (IC50 values of 0.23 and 0.47 µM, respectively), and reduces activity against other kinases (c-src, casein kinase 2, ERK1 and ERK2 have … WebHILPDA hepatocyte-specific knockout C57BL/6J mice (Hilpda ΔHep) were generated by crossing homozygous C57BL/6J Hilpda loxP-flanked (Hilpda fl/fl) mice (STOCK Hilpdatm1.1Nat/J, The Jackson Laboratory, strain n. 017360; backcrossed onto C57BL/6J at least 8 times in Mayo Clinic animal facilities) with C57BL/6J Albumin-Cre (B6.Cg-Speer6 … pt samyou international

Targeted Deletion of HIF-1α Gene in T Cells Prevents their …

Web15 sep. 2016 · Abstract. Conditional gene targeting using the bacteriophage-derived Cre recombinase is widely applied for functional gene studies in mice. Mice transgenic for … Web21 jan. 2024 · 它指的是在老鼠的基因组中插入了一个连接有mCherry的Cre片段，该片段在XCr1启动子的控制之下，只会在cDC1细胞表达。表达时，mCherry和Cre会被内源酶切开，mCherry用来指示表达的细胞，而Cre产生作用。 Cre产生什么作用呢？它会识别loxP-flanked序列，将序列之后的基因敲除，因而称作conditional KO。所以，你看到的 … WebTg (Lck-cre)I57Jxm Transgene Detail MGI Mouse (MGI:2177584) Tg (Lck-cre)I57Jxm Transgene Detail Summary Transgene origin Transgene description Recombinase … pt san sheng wood

012837 - dLck-hcre[3779] Strain Details - The Jackson …

WebLa Bibliothèque Virtuelle de Santé est une collection de sources d'information scientifiques et techniques en santé, organisée et stockée dans un format électronique dans les pays de la Région d'Amérique Latine et des Caraïbes, universellement accessible sur Internet et compatible avec les bases de données internationales. WebGenotyping PCR protocol. 寄託者から提供された情報に基づいて遺伝検査を実施しています。. 検査項目については、マウス系統の品質管理をご覧ください。. 遺伝検査で使用している機器・試薬に関しては、機器・試薬一覧（使用中のメーカー）をご覧ください ... hot cocoa bombs and mugsWebTg (Lck-cre)I57Jxm Transgene Detail MGI Mouse (MGI:2177584) Tg (Lck-cre)I57Jxm Transgene Detail Summary Transgene origin Transgene description Recombinase activity Phenotypes Find Mice (IMSR) References Summary Transgene origin Strain of Origin: ICR Transgene description Recombinase activity Phenotypes pt sam and andy

"Web18 dec. 2014 · Although all p53−/−;Lck-Cre;Bcl-xfl/+ mice developed cancer, the proportion of mice exhibiting thymic lymphoma was reduced compared with p53−/−;Lck-Cre mice ( Figure 1B ). This reduction in thymic lymphoma incidence was compensated by an increase in other tumors (eg, splenomegaly and sarcoma). " - Lck-cre mouse

Lck-cre mouse

Zinc finger protein Zfp335 controls early T-cell development and ...

Web21 mei 2024 · We generated Tfam fl/fl Lck Cre mice, in which Cre recombinase is expressed under the control of the lymphocyte protein tyrosine kinase (Lck) promoter. Tfam fl/fl Lck Cre mice presented comparable metabolic and functional alterations in T cells and similar premature age-associated multimorbidity to those observed in Tfam fl/fl Cd4 Cre … Web1 2 Lck-Cre小鼠分类: Cre鼠发布时间: 2024-07-11 11:00 应用：免疫系统级别：SPF 类型：TG/KI 背景：C57BL/6 该Cre小鼠与FloxP小鼠交配后，在Cre特异表达的组织或者器官或细胞中，两个FloxP位点间的外显子或元件将被删除，达到条件性敲除或过表达的目的。 Cre-loxP重组系统是一种位点特异的基因重组技术，被广泛应用于特异位点的基因敲除、基 …

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Web022071 B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ CD4-Cre transgenic mice contain CD4 enhancer, promoter and silencer sequences driving the expression of a Cre recombinase gene. … WebThe Ctcf f/fl mice 7 were provided by Rudi Hendriks (Erasmus Medical Center Rotterdam). The Lck-cre mice 95 were purchased from Taconic (Rensselaer, NY). Further details are listed in the key resources table. The mice were bred and/or maintained at the animal care facilities of the Erasmus Medical Center Rotterdam and the Hubrecht Institute.

Web7 feb. 2024 · Vil/Cre mice had signiﬁcant shortening of the colon compared with their respective control groups (Figure1C). Interestingly, CerS4 LCK/Cre mice developed signiﬁcantly more colon tumors than CerS4 WT, CerS4 KO, and CerS4 Vil/Cre mice. Although the tumor number was higher in AOM/DSS-treated CerS4 LCK/Cre mice, the … WebTamoxifen诱导Cre-ERT2小鼠使用指南. Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。. 查看. 【小鼠大学问】基因工程小鼠的命名规则. 常见的 ...

Web12 okt. 2024 · Generation of Rosa26 Flox-Stop-Flox-IRES-Ncr1 mouse and crossing with CD2 cre and LCK cre mice. ( A) Schematic representation of the Rosa locus-targeting … WebThe thymus of Mof (F/F)/Lck-Cre (+) mice contained significantly reduced T cells, whereas thymic B cells were elevated. Within the T-cell population, CD4 (+)CD8 (+) double …

Web4 mrt. 2024 · 首先最基础的小鼠，C57BL/6，它是一种常见的近交品系实验鼠，我们常听到的 “C57”或者“B6”都是它。因为该小鼠品系已经完成了基因组测序，且对许多肿瘤不易发，但能够发生饮食诱导性肥胖和动脉粥样硬化等。声明：该文观点仅代表作者本人，搜狐号系信息发布平台，搜狐仅提供信息存储空间服务。首赞阅读 () 0 人参与， 0 条评论

Web31 aug. 2024 · In the current study, we crossed Tcf7fl/fl mice with Vav -cre, 32 Lck -cre, 33 or Cd4 -cre 33 transgenic mice to conditionally inactivate Tcf-1 at different … hot cocoa bombs deliveryWebAlthough these investigators observed an improved imiquimod-induced psoriasiform phenotype with keratinocyte-specific ablation of Hmgb1, knockout of the Hmgb1 gene in dendritic cells (using Itgax promoter-driven Cre in Hmgb1 floxed mice), myeloid cells (Lyz2 promoter-driven Cre) or T cells (Lck promoter-driven Cre) produced no significant effect. … pt sanwoo electronicsWebAn Journal of Objective Investigation; Current issue; Past issues; Product; Reviews; Review series; Videos; Conversations with Giant to Drugs pt sambhunath universityWeb5 sep. 2007 · Constitutively synthesized HIF-1 α mRNA was detected in control (lck-Cre negative) but not in (lck-Cre positive) HIF1 α gene targeted mice. N = 3 per group. C: T cell lineage specific HIF-1 α deficient mice are more resistant to lethal sepsis after cecal ligation and puncture procedure. Mice underwent CLP and were observed for mortality. hot cocoa bombs with mugWebT-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. When using the Lck-Cre 548-O mouse strain in a publication, … hot cocoa bombs precioWebTo validate this mouse strain, we crossed Ctla4fl/fl to LckCre + mice to generate LckCre+Ctla4fl/fl mice, which would delete Ctla4 in T cells expressing Lck during thymic selection. These mice displayed a very similar phenotype to germline Ctla4 knockout mice, developing massive lymphadenopathy and dying by 28 d of age (unpublished data). pt satish vyasWebLck-cre 转基因小鼠: 资源英文名称: B6.Cg-Tg(Lck-cre) 疾病概述: cre工具小鼠: 实验动物背景信息: C57BL/6J. 模型制作方法: 转基因小鼠 . 模型表型数据: Lck基因主要由T淋巴细胞 … pt sanwa screen indonesia