Simon's minimax two-stage design

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August undefined, 2024

WebbLater, the Simon ( 1989) optimal two-stage design considered the smallest expected sample size under the null hypothesis as an optimization criterion to stop only for futility. Another criterion that minimized the maximum sample size … WebbSimonのMinimax法薬剤が無効な場合に早期中止を判断するための2段階デザイン無効な場合の患者数の最大値を最小にしたい．手順はSimonの最適法と同様 ※Simon …

用于 II 期肿瘤学临床试验的最佳、极小和可接受的两阶段设计 …

Webb略説 Simon's two stage design に対するサンプルサイズ設計を行う Web アプリです、JavaScript で作成しています。本ソフトウェアは R の clinfun package のアルゴリズム … http://fmwww.bc.edu/repec/bocode/s/simon2stage.sthlp can i use kale instead of spinach

Stata Journal Article

Webbpractically synonymous with the Simon’s optimal and MINIMAX two stage (1989) –designs which have stood the test of time with their pracmatic trade-off between the need to stop a trial early for inefficacy if response rates were low and the likely overshoot of interim analysis in small trials.” Roger A’Hern (2014) WebbSimon’s two-stage designs are popular single-arm, binary-endpoint clinical trials that include a single interim analysis for futility. In the literature, it is widely acknowledged … Webb1 juli 2024 · The trial uses a Simon's minimax two-stage design. We hypothesized that excluding a CBR ≤5% while targeting an improvement of the CBR to ≥20% would be an … can i use kcd on a mac

A predictive probability design for phase II cancer clinical trials

188-2007: Using SAS® to Determine Sample Sizes for Traditional …

Webb12 aug. 2024 · Simon establishes his designs by checking for every total sample size N, each possible division into two stages, those that satisfy these conditions. From these … Webb15 apr. 2024 · 2 Department of Biostatistics, MD Anderson Cancer Center, Houston, TX 77030. ... Optimal Minimax. Calculate. Design Summary; Protocol Template; Reference; … can i use karcher universal cleaner on my carWebbconducted using single-arm two-stage designs with a futility interim test by recruiting about 50 patients. Since Rich Simon proposed optimal design and minimax design for … fiver cable

"WebbSimon两阶段设计常用于肿瘤药物单臂两阶段试验，具有节省样本量，早期发现试验无效及时终止试验，避免受试者接受无效治疗，节省时间和成本，更加符合伦理要求的特点。 … " - Simon's minimax two-stage design

Simon's minimax two-stage design

WebbDownloadable! This article describes a new Stata command called simontwostage, which calculates the critical values and sample sizes for two-stage designs for phase II … Webb15 apr. 2016 · Simon's optimal two‐stage design has been widely used in early phase clinical trials for Oncology and AIDS studies with binary endpoints. With this approach, the second‐stage sample size is fixed when the trial passes …

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WebbThe commonly used Simon’s designs [8] are also two-stage designs. Simon’s designs allow early stopping due to futility, i.e., when lack of efficacy is observed. If the experimental treatment works well, more patients are treated in the second stage, which also allows better estimation of the response rate and toxicity of the new treatment ... Webb28 juli 2024 · Since Rich Simon proposed optimal design and minimax design for two-stage phase II trials in 1986, either of them has been chosen for most of phase II clinical …

Webb2 aug. 2016 · The null hypothesis is rejected for a large response rate. Let n 1, n 2, and n be the number of subjects enrolled in the first stage, the … Webb1 juni 2024 · In this article, we propose optimal and minimax two-stage basket trial designs for exploratory clinical trials. Inactive tumor indications are pruned in stage 1 and the active tumor...

Webb3 apr. 2024 · Methods We propose a new single-arm two-stage optimal design with survival endpoint by using the one-sample log rank test based on exact variance estimates. This proposed design with survival... WebbSimon’s like design with relaxed futility stopping Two-stage design for ordinal outcomes The Rapid Enrollment Design (RED) for Phase I trials Other programs Simon's Two-Stage …

WebbThe minimax design is more popular than the optimal design. Simon two-stage design is better than single-stage design and Gehan two-stage design. The minimax design is …

Webb1 juli 2024 · Compared with the Gehan two-stage design, the Simon two-stage design has the advantage of being able to determine an early termination of trials when no or low … can i use jr pass in kyoto subwayWebb描述：计算 Richard Simon 给出的 Optimal 和 Minimax 2 阶段 Phase II 设计. 用法：ph2simon (pu, pa, ep1, ep2, nmax=100) 参数说明：. pu：不可接受的响应率. pa：理想的响应率. ep1：I类错误（alpha，α）. ep2：II类错误（beta，β）. nmax：最大总样本量（默认为 100；最多为 500）. ph2simon ... can i use k cups in nespressoWebbSimon’s minimax design is the one that minimizes the maximum sample size, such that both the α and β constraints are satisfied. The graph to the right is used to illustrate the … fiver channelWebb2 juli 2024 · Modified Simon's minimax and optimal two-stage designs for single-arm phase II cancer clinical trials. Simon's two-stage design and the admissible two-stage … can i use kefir whey in recipesWebbDescription Calculates Optimal and Minimax 2-stage Phase II designs given by Richard Simon Usage ph2simon (pu, pa, ep1, ep2, nmax=100) # S3 method for ph2simon print (x, … fiver changeWebb1 aug. 2001 · A two-stage design is defined by the number of patients to be accrued at each stage ( n1 and n2) and the boundary values at stages 1 and 2 ( r1 and r ). Let p0 denote the maximum unacceptable probability of response and p1 denote the minimum acceptable probability of response ( p0 < p1 ). can i use ketoconazole cream on my dogWebb15 dec. 1997 · This work proposes single-stage and two-stage designs for randomized phase II clinical trials, and develops a program to compute various type I error rates and powers exactly to achieve this objective. 6 A new adaptive design based on Simon's two-stage optimal design for phase II clinical trials. Hua Jin, Zhen Wei Mathematics can i use kefir instead of buttermilk